To provide a brief data on Structure and processing of the ND-contained materials and try to explore more details on effectiveness of the modified or developed ND-contained materials in medical implant, tissue scaffolds, or medical imaging. The in-depth study of the medical application might be necessary to provide in-depth review and discussion on efficacy of the ND-contained materials for improvement of the clinical outcomes while expressing the current challenges in this regard.

Response: Dear reviewer, thanks for your comment. As you suggested, more studies were added to the medical applications (section 5.1 and 6, yellow highlighted) as below:

“Zhang et al. [117] prepared the multimodal nanodiamonds by attaching monoclonal antibodies and drug‐oligonucleotide conjugates labeled by fluorescent onto the surface of ND. They reported that by these linkers, it is possible to quantify the ND conjugates and observe intercellular regions. Dong et al. [118] prepared fluorescent nanodiamond-based composites by a simple and novel method. The hydrophilic polymer/ functionalized ND composite was reported to be suitable for different biomedical applications because of their good potential and physicochemical properties. Also, they reported that these samples have strong fluorescence intensity, low toxicity, and high water dispersibility. According to the result of cell uptakes, the cells could internalize the fluorescent nanodiamond-based composites. Sarkar et al. [119] used a new background-free imaging method and reported that this technique enhances the ratio of signal-to-background up to 100 times. Also, an improvement was observed in the fluorescent nanodiamond imaging capabilities on diverse fluorescence imaging platforms.”